|
KMID : 0361019960390060980
|
|
Korean Journal of Otolaryngology - Head and Neck Surgery
1996 Volume.39 No. 6 p.980 ~ p.992
|
|
|
Clinical Significane of the Expression of TGF-alph and TGF-beta in Squamous Cell Carcinoma of the Larynx and Hypopharynx
|
|
박일석
김시환/김승현/정인교/김형종/노영수/임현준
|
|
|
Abstract
|
|
|
The clinical staging systems for laryngeal and hypopharyngeal cancer is limited as a prognostic indicator. This is due to several factors including different biological characteristics of cancer in this region and various microenvironmental
effects
depending on subsites.
For determining prognostic indicators, the author performed 28 cases of immunohistochemical staining on transforming growth factors alpha and beta in surgically treated squamous cell carcinoma of the larynx and hypopharynx.
The following results were obtained. The rate of TGF-alpha expression compared with clinical and pathological status of tumor exhibited poor prognostic significance. The strong expression of TGF-beta correlated with nodal metastasis, positive
extracapsular spread, recurrence and distant metastasis.
In conclusion, the expression rate of TGF alpha and TGF-bet not only reflected the biological behavior of cancer, but correlated closely with the tumor factors. However, these indicators related with tumor factors in complicated patterns.
Therefore, the
immunohistochemical study of TGF-alpha and TGF-beta may be considered as an adjuvant method for supporting the reliability of tumor factor as a prognostic indication of laryngeal and hypopharyngeal squamous cell carcinoma. (Korean J Otolaryngo1
39
: 6,
1996)
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|